One player who could have played his last game for Rangers is midfielder Ianis Hagi, who Ferguson confirmed will miss the rest of the season injured with his contract running out shortly.
Also soon to be out of contract are defender Leon Balogun and midfielder Tom Lawrence, while loans for defenders Rafael Fernandes and Nerayasho Kasanwjiro and wingers Vaclav Cerny and Oscar Cortes are nearing their end.
Injury plagued Cortes, 21, is still likely to be at Ibrox next season unless Rangers can negotiate their way out of an obligation to purchase from Lens. The Columbia international has featured just 14 times in 16 months across his two loan spells.
Defenders John Souttar and James Tavernier, the latter the club captain, will soon enter the final year of their contracts.
Dundee midfielder Lyall Cameron is on his way to Rangers after agreeing a pre-contract but no other deals have been announced as yet.
“In terms of the guys that are running out of contract, no, I’ve not had any involvement in terms of what I would do and what obviously the players are thinking of doing,” said Ferguson.
“It’s a bit of a sticky situation, if I’m being honest with you. It’s hard and I’ve got to be honest, I think the players find it hard as well. But again, all I can ask is that they be as professional as possible, which they have again this week.
“We’ve got to be fair to them, we’ve kept our heads down, we’ve worked hard.”
Ferguson has been in charge for 12 games since replacing Philippe Clement in February but has won just four, drawing four and losing four.
He is yet to win at Ibrox as Rangers boss and has two more opportunities this season – against Aberdeen on Sunday (12:00 BST) and against Dundee United on Wednesday (19:45).
Rangers complete their season away to Hibernian on 17 May (12:30).
And Ferguson added: “There has been a couple of changes made, and obviously there needs to be a few changes made in terms of what manager is going to be taking the team next year, and who’s going to be staying, who’s going to be going, signings coming in, etc.
“The 22 July, it’s the first qualifying game for the Champions League. That’s just around the corner, so we need to be wary of that as well.”
